Scientific References for Newsletter # 17
Firth, J. , Teasdale, S. B., Allott, K. , Siskind, D. , Marx, W. , Cotter, J. , Veronese, N. , Schuch, F. , Smith, L. , Solmi, M. , Carvalho, A. F., Vancampfort, D. , Berk, M. , Stubbs, B. and Sarris, J. (2019), The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta‐review of meta‐analyses of randomized controlled trials. World Psychiatry, 18: 308-324. doi:10.1002/wps.20672
Briggs R, McCarroll K, O'Halloran A, Healy M, Kenny RA, Laird E. Vitamin D Deficiency Is Associated With an Increased Likelihood of Incident Depression in Community-Dwelling Older Adults. J Am Med Dir Assoc. 2019 May;20(5):517-523. doi: 10.1016/j.jamda.2018.10.006. Epub 2018 Nov 20. PubMed PMID: 30470577.
DiNicolantonio JJ, O'Keefe JH. The Importance of Marine Omega-3s for Brain Development and the Prevention and Treatment of Behavior, Mood, and Other Brain Disorders. Nutrients. 12(8):E2333. 2020 Aug.
Scientific References for Newsletter # 16
https://www.hopkinsmedicine.org/news/media/releases/calcium_supplements_may_damage_the_heart
Scientific References for Newsletter # 12
Ogawa A, Kadooka Y, Kato K, Shirouchi B, Sato M. Lactobacillus gasseri SBT2055 reduces postprandial and fasting serum non-esterified fatty acid levels in Japanese hypertriacylglycerolemic subjects. Lipids Health Dis. 2014;13:36. Published 2014 Feb 19. doi:10.1186/1476-511X-13-36
Ooi LG, Ahmad R, Yuen KH, Liong MT. Lactobacillus gasseri [corrected] CHO-220 and inulin reduced plasma total cholesterol and low-density lipoprotein cholesterol via alteration of lipid transporters. J Dairy Sci. 2010 Nov;93(11):5048-58. doi: 10.3168/jds.2010-3311. PubMed PMID: 20965319.
Martínez-Cañavate A, Sierra S, Lara-Villoslada F, Romero J, Maldonado J, Boza J, Xaus J, Olivares M. A probiotic dairy product containing L. gasseri CECT5714 and L. coryniformis CECT5711 induces immunological changes in children suffering from allergy. Pediatr Allergy Immunol. 2009 Sep;20(6):592-600. doi: 10.1111/j.1399-3038.2008.00833.x. Epub 2009 Jul 8. PubMed PMID: 19594864.
Shahani, K.M., Vakil, J.R., Kilara A. Natural antibiotic activity of L. acidophilus and bulgaricus. II. Isolation of acidophilin from L. acidophilus. Cult Dairy Prod J 1977; 12:8–11.
Goyal N., Dixit K., Gandhi DN. Antimicrobial activity of probiotic Lactobacillus strains towards Salmonella enterica ser enteritidis in whey. Int J Microbiol 2008; 5:1277–82.
Shahani, K.M., Vakil, J.R., Kilara A. Natural antibiotic activity of L. acidophilus and bulgaricus. I. Cultural conditions for the production of antibiosis. Cult Dairy Prod J 1976; 11:14–7.
Polewski, M.A., Krueger, C.G., Reed, J.D., Leyer G. Ability of cranberry proanthocyanidins in combination with a probiotic formulation to inhibit in vitro invasion of gut epithelial cells by extra-intestinal pathogenic E. coli. J Funct Foods 2016; 25:123–34.
Chatterjee, A., Yasmin, T., Bagchi, D., Stohs S. The bactericidal effects of Lactobacillus acidophilus, garcinol and Protykin® compared to clarithromycin, on Helicobacter pylori. Mol Cell Biochem 2003; 243:29–35.
Vemuri R, Shinde T, Shastri MD, Perera AP, Tristram S, Martoni CJ, Gundamaraju R, Ahuja KDK, Ball M, Eri R. A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics. Int J Med Sci 2018; 15:840–8.
Pakdaman MN, Udani JK, Molina JP, Shahani M. The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial. Nutr J. 2016;15(1):56. Published 2016 May 20. doi:10.1186/s12937-016-0172-y
Pakdaman MN, Udani JK, Molina JP, et al. Nutr J 2016;15:56.
Nagala R, Routray C. US Gastroenterol Hepatol Rev 2011;7:36-7.
Gerasimov SV, Ivantsiv VA, Bobryk LM, et al. Eur J Clin Nutr 2016;70:463–9.
Gerasimov SV, Vasjuta VV, Myhovych OO et al. Am J Clin Dermatol 2010;11:351–61.
Mu Q, Tavella VJ, Luo XM. Role of Lactobacillus reuteri in Human Health and Diseases. Front Microbiol. 2018;9:757. doi: 10.3389/fmicb.2018.00757. eCollection 2018. Review. PubMed PMID: 29725324; PubMed Central PMCID: PMC5917019.
Kadooka Y, Sato M, Imaizumi K, Ogawa A, Ikuyama K, Akai Y, Okano M, Kagoshima M, Tsuchida T. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr. 2010 Jun;64(6):636-43. doi: 10.1038/ejcn.2010.19. Epub 2010 Mar 10. PubMed PMID: 20216555.
Nagala, R., Routray C. Clinical Case Study—Multispecies probiotic supplement minimizes symptoms of irritable bowel syndrome. US Gastroenterol Hepatol Rev 2011; 7.
Scientific References for Newsletter # 11
Scientific References for Newsletter # 10
https://openheart.bmj.com/content/3/1/e000325.full
Scientific References for Newsletter # 9
https://www.hopkinsmedicine.org/news/media/releases/calcium_supplements_may_damage_the_heart
Accessed 4/4/2019
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069646/
Accessed 4/4/2019
Arnab Kar, Sumana Datta: A study of serum Vitamin D level and its association with hypertension. J Family Med Prim Care. 2018 May-Jun; 7(3): 546–550.
https://lpi.oregonstate.edu/mic/vitamins/vitamin-D
Accessed 4/4/2019
https://www.jamda.com/article/S1525-8610(18)30579-6/fulltext
Accessed 5/14/19
Robert Briggs, MB, BCh, BAO, Kevin McCarroll, MD, Aisling O'Halloran, PhD, Martin Healy, PhD, Rose Anne Kenny, MD, Eamon Laird, PhD: Vitamin D Deficiency Is Associated With an Increased Likelihood of Incident Depression in Community-Dwelling Older Adults. Journal of the American Medical Directors Association, Volume 20, Issue 5, 517 – 523 Published Online November 20, 2018
https://ods.od.nih.gov/factsheets/vitaminK-HealthProfessional/
Accessed 4/25/19
https://ods.od.nih.gov/factsheets/vitaminK-HealthProfessional/
Accessed 4/25/19
Scientific References for Newsletter # 8 Fall 2019
Maes M, Christophe A, Delanghe J, Altamura C, Neels H, Meltzer HY. Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients. Psychiatry Res. 1999;85:275-91.
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Nutritional composition referencesExler, J. (1987) Composition of Foods: Finfish and Shellfish Products. Agriculture handbook No. 8-15. Washington, DC: USDA
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George Leef, MD; Zackary Goff, MD; Roger S. Blumenthal, MD, FACC; Seth Shay Martin, MD, MHS, FACC, EPA Rises From a Dead Sea of Omega-3: The Landmark REDUCE-IT Trial, https://www.acc.org/latest-in-cardiology/articles/2018/11/28/06/11/epa-rises-from-a-dead-sea-of-omega-3, accessed 3/4/2019
Scientific References for Newsletter # 7
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Oben J, Kothari SC, Anderson ML: An open label study to determine the effects of an oral proteolytic enzyme system on whey protein concentrate metabolism in healthy males. J Int Soc Sports Nutr. 2008 Jul 24;5:10. doi: 10.1186/1550-2783-5-10.
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Anderson ML: A Double-Blind Clinical Study to Investigate the Effects of a Fungal Protease Enzyme System on Metabolic, Hepato-renal, and Cardiovascular Parameters Following 30 Days of Supplementation in Active, Healthy Men. Food Dig. 2013 May;4(1):19-25. Epub 2011 Dec 13.
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Whey Protein Monograph. Alternative Medicine Review Volume 13, Number 4 2008
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Scientific References for Newsletter # 6 Fall 2018
Li Y, Jiang L, Jia Z, et al. A Meta-Analysis of Red Yeast Rice: An Effective and Relatively Safe Alternative Approach for Dyslipidemia. Calabresi L, ed. PLoS ONE. 2014;9(6):e98611. doi:10.1371/journal.pone.0098611.
Heber D., Lembertas A., Lu Q. Y., Bowerman S., Go V. L. An analysis of nine proprietary Chinese red yeast rice dietary supplements: implications of variability in chemical profile and contents. Journal of Alternative and Complementary Medicine. 2001;7(2):133–139. doi: 10.1089/107555301750164181.
Gordon RY, Cooperman T, Obermeyer W, Becker DJ. Marked variability of monacolin levels in commercial red yeast rice products: buyer beware! Arch Intern Med. 2010 Oct 25;170(19):1722-7. doi: 10.1001/archinternmed.2010.382. PubMed PMID: 20975018.
Bogsrud MP, Ose L, Langslet G, Ottestad I, Strøm EC, Hagve TA, Retterstøl K. HypoCol (red yeast rice) lowers plasma cholesterol - a randomized placebo controlled study. Scand Cardiovasc J. 2010 Aug;44(4):197-200. doi: 10.3109/14017431003624123. PubMed PMID: 20636227.
Caswell, H. , Denny, A. and Lunn, J. (2008), Plant sterol and stanol esters. Nutrition Bulletin, 33: 368-373. doi:10.1111/j.1467-3010.2008.00740.x
Ostlund RE Jr. Phytosterols in human nutrition. Annu Rev Nutr. 2002;22:533-49. Epub 2002 Apr 4. Review. PubMed PMID: 12055357.
Acuff RV, Cai DJ, Dong Z-P, Bell D. The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects. Lipids in Health and Disease. 2007;6:11. doi:10.1186/1476-511X-6-11.
Jones PJ, Demonty I, Chan YM, Herzog Y, Pelled D. Fish-oil esters of plant sterols differ from vegetable-oil sterol esters in triglycerides lowering, carotenoid bioavailability and impact on plasminogen activator inhibitor-1 (PAI-1) concentrations in hypercholesterolemic subjects. Lipids Health Dis. 2007 Oct 25;6:28. PubMed PMID: 17961204; PubMed Central PMCID: PMC2194675.
Berger A, Jones PJ, Abumweis SS. Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids in Health and Disease. 2004;3:5. doi:10.1186/1476-511X-3-5.
Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R; Stresa Workshop Participants.. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc. 2003 Aug;78(8):965-78. Review. PubMed PMID: 12911045.
De Jong A, Plat J, Bast A, Godschalk RW, Basu S, Mensink RP. Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment. Eur J Clin Nutr. 2008 Feb;62(2):263-73. Epub 2007 May 9. PubMed PMID: 17487211.
Scientific References for Newsletter # 5 Summer 2018
Ross BM, Mckenzie I, Glen I, Bennett CP. Increased levels of ethane, a non-invasive marker of n-3 fatty acid oxidation, in breath of children with attention deficit hyperactivity disorder. Nutr Neurosci. 2003;6(5):277-81.
Richardson AJ. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry. 2006;18(2):155-72.
Montgomery P, Burton JR, Sewell RP, Spreckelsen TF, Richardson AJ. Low blood long chain omega-3 fatty acids in UK children are associated with poor cognitive performance and behavior: a cross-sectional analysis from the DOLAB study. PLoS ONE. 2013;8(6):e66697.
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Derbyshire E. Do Omega-3/6 Fatty Acids Have a Therapeutic Role in Children and Young People with ADHD?. J Lipids. 2017;2017:6285218.
Raine A, Portnoy J, Liu J, Mahoomed T, Hibbeln JR. Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years: a randomized, double-blind, placebo-controlled, stratified, parallel-group trial. J Child Psychol Psychiatry. 2015;56(5):509-20.
Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002;56(8):365-79.
Scientific References for Newsletter # 4 Spring 2018
Gupta SC, Patchva S, Aggarwal BB. Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. The AAPS Journal. 2013;15(1):195-218. doi:10.1208/s12248-012-9432-8.
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Zhang J-M, An J. Cytokines, Inflammation and Pain. International anesthesiology clinics. 2007;45(2):27-37. doi:10.1097/AIA.0b013e318034194e.
Anft M. Understanding Inflammation. Johns Hopkins Health Review. 2016;3(1).
Scientific References for Newsletter # 3 Fall 2017
More than one quarter of all adults in the United States take a statin for control of cholesterol.1
Joseph A. Salami, et. al., 2017, National Trends in Statin Use and Expenditures in the US Adult Population From 2002 to 2013; Insights From the Medical Expenditure Panel Survey, JAMA Cardiol. 2017;2(1):56-65. http://jamanetwork.com/journals/jamacardiology/article-abstract/2583425, accessed 9/8/17
While the risk of serious side effects is low, myopathy is the most common side effect of statin use.2
The most common statin-related myopathy in patients is pain in the thighs, calves or both.3
Littlefield N, Beckstrand RL, Luthy KE, 2014, Statins’ effect on plasma levels of Coenzyme Q10 and improvement in myopathy with supplementation, J Am Assoc Nurse Pract. 2014 Feb;26(2):85-90. doi: 10.1002/2327-6924.12046. Epub 2013 Jul 12
Statins can effectively block the cholesterol the body naturally produces, but they can also reduce natural production of CoQ10, a molecule that is essential for cellular health, especially in tissue with high rates of metabolism, such as the heart, kidney and liver.4
Littlefield N, Beckstrand RL, Luthy KE, 2014, Statins’ effect on plasma levels of Coenzyme Q10 andimprovement in myopathy with supplementation, J Am Assoc Nurse Pract. 2014 Feb;26(2):85-90. doi: 10.1002/2327-6924.12046. Epub 2013 Jul 12
Saini R, 2011, Coenzyme Q10: The essential nutrient, J Pharm Bioallied Sci. 2011 Jul-Sep; 3(3): 466–467.
Reduced levels of CoQ10 are closely associated with heart disease, muscular problems and numerous other dangerous health conditions.5
Quinzii CM, DiMauro S, Hirano M, 2007, Human Coenzyme Q10 Deficiency, Neurochem Res. 2007 Apr; 32(4-5): 723–727
The human body also uses CoQ10 to neutralize “free radicals”, highly reactive molecules that can damage our cells and contribute to aging.6
Saini R, 2011, Coenzyme Q10: The essential nutrient, J Pharm Bioallied Sci. 2011 Jul-Sep; 3(3): 466–467.
A meta-analysis study of eight studies on CoQ10 supplementation showed improved stroke volume, cardiac output, ejection fraction, cardiac index and end diastolic volume index – in short, improved heart health.7
Soja AM1, Mortensen SA., 1997, Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials, Mol Aspects Med. 1997;18 Suppl:S159-68
Figure 1 & Figure 3
Kalen A, Appelkvist EL, Dallner G. 1989, Age-related changes in the lipid compositions of rat and human tissues, Lipids, 1989 Jul; 24(7):579-84
Scientific References for Newsletter # 2 Summer 2017
Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2003;348(13):1215–1222. doi: 10.1056/NEJMoa022066.
Littlefield N, Beckstrand RL, Luthy KE, 2014, Statins’ effect on plasma levels of Coenzyme Q10 and
improvement in myopathy with supplementation, J Am Assoc Nurse Pract. 2014 Feb;26(2):85-90. doi: 10.1002/2327-6924.12046. Epub 2013 Jul 12
Ogawa A, Kadooka Y, Kato K, Shirouchi B, Sato M. Lactobacillus gasseri SBT2055 reduces postprandial and fasting serum non-esterified fatty acid levels in Japanese hypertriacylglycerolemic subjects. Lipids Health Dis. 2014;13:36. Published 2014 Feb 19. doi:10.1186/1476-511X-13-36Ooi LG, Ahmad R, Yuen KH, Liong MT. Lactobacillus gasseri [corrected] CHO-220 and inulin reduced plasma total cholesterol and low-density lipoprotein cholesterol via alteration of lipid transporters. J Dairy Sci. 2010 Nov;93(11):5048-58. doi: 10.3168/jds.2010-3311. PubMed PMID: 20965319.Martínez-Cañavate A, Sierra S, Lara-Villoslada F, Romero J, Maldonado J, Boza J, Xaus J, Olivares M. A probiotic dairy product containing L. gasseri CECT5714 and L. coryniformis CECT5711 induces immunological changes in children suffering from allergy. Pediatr Allergy Immunol. 2009 Sep;20(6):592-600. doi: 10.1111/j.1399-3038.2008.00833.x. Epub 2009 Jul 8. PubMed PMID: 19594864.Shahani, K.M., Vakil, J.R., Kilara A. Natural antibiotic activity of L. acidophilus and bulgaricus. II. Isolation of acidophilin from L. acidophilus. Cult Dairy Prod J 1977; 12:8–11. Goyal N., Dixit K., Gandhi DN. Antimicrobial activity of probiotic Lactobacillus strains towards Salmonella enterica ser enteritidis in whey. Int J Microbiol 2008; 5:1277–82.Shahani, K.M., Vakil, J.R., Kilara A. Natural antibiotic activity of L. acidophilus and bulgaricus. I. Cultural conditions for the production of antibiosis. Cult Dairy Prod J 1976; 11:14–7. Polewski, M.A., Krueger, C.G., Reed, J.D., Leyer G. Ability of cranberry proanthocyanidins in combination with a probiotic formulation to inhibit in vitro invasion of gut epithelial cells by extra-intestinal pathogenic E. coli. J Funct Foods 2016; 25:123–34.Chatterjee, A., Yasmin, T., Bagchi, D., Stohs S. The bactericidal effects of Lactobacillus acidophilus, garcinol and Protykin® compared to clarithromycin, on Helicobacter pylori. Mol Cell Biochem 2003; 243:29–35.Vemuri R, Shinde T, Shastri MD, Perera AP, Tristram S, Martoni CJ, Gundamaraju R, Ahuja KDK, Ball M, Eri R. A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics. Int J Med Sci 2018; 15:840–8.Pakdaman MN, Udani JK, Molina JP, Shahani M. The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial. Nutr J. 2016;15(1):56. Published 2016 May 20. doi:10.1186/s12937-016-0172-yPakdaman MN, Udani JK, Molina JP, et al. Nutr J 2016;15:56.Nagala R, Routray C. US Gastroenterol Hepatol Rev 2011;7:36-7.Gerasimov SV, Ivantsiv VA, Bobryk LM, et al. Eur J Clin Nutr 2016;70:463–9.Gerasimov SV, Vasjuta VV, Myhovych OO et al. Am J Clin Dermatol 2010;11:351–61.Mu Q, Tavella VJ, Luo XM. Role of Lactobacillus reuteri in Human Health and Diseases. Front Microbiol. 2018;9:757. doi: 10.3389/fmicb.2018.00757. eCollection 2018. Review. PubMed PMID: 29725324; PubMed Central PMCID: PMC5917019.Kadooka Y, Sato M, Imaizumi K, Ogawa A, Ikuyama K, Akai Y, Okano M, Kagoshima M, Tsuchida T. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr. 2010 Jun;64(6):636-43. doi: 10.1038/ejcn.2010.19. Epub 2010 Mar 10. PubMed PMID: 20216555.Nagala, R., Routray C. Clinical Case Study—Multispecies probiotic supplement minimizes symptoms of irritable bowel syndrome. US Gastroenterol Hepatol Rev 2011; 7.